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30016 Cytotoxic ruthenium complexes

Several research groups have reported that certain transition metal complexes bind reversibly to DNA, whereupon they function as “light switches” i.e. display luminescence which is absent (quenched) in aqueous media.  Scientists at the University of Sheffield have been investigating the properties of one such group of mononuclear ruthenium (II) polypyridyl complexes.

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